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GastroDefense and Leaky Gut Syndrome

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GastroDefense

A Healthy Gut is the Key to Health

by John I. Buhmeyer, MS

There are a lot of benefits to modern living, but along with the benefits come problems. Maintaining a healthy gut is one of them.  Taking pain medications such as NSAIDs1 and antibiotics2, drinking alcohol3,4, coffee or soft drinks, stress, environmental toxins – they all take their toll on your gut5.  All of these can contribute to increased permeability of the gut lining, called leaky gut syndrome, which allows things like pathogenic (disease-causing) microorganisms and toxins to get through into our blood streams that normally would be kept out.  This is the source of many, if not the majority, of diseases that afflict modern man6,7, including more serious diseases of the gut, such as irritable bowel syndrome, Crohn’s disease8,9, spondyloarthropathies and other arthritic diseases10, 11,12,13, acne, eczema, psoriasis14, urticaria (hives), cystic fibrosis15, and anumber of other diseases16.

Leaky gut syndrome can lead to food allergies as a result of food particles being absorbed into the bloodstream where antibodies can be made against the proteins inthem.  The gut wall becomes inflamed, interfering with nutrient absorption, resulting innutrient deficiencies.  Chemical sensitivities can develop due to the disruption of normal detoxification pathways in the gut.  You may develop systemic symptoms like fatigue, headaches, memory loss, poor concentration, irritability, diarrhea, food intolerances, abdominal pain, skin rashes, shortness of breath, and fevers of unknown origin. Antibodies produced by lymphatic tissues in the gut can be absorbed into the bloodstream where antibodies are made against these antibodies.  This may be one ofthe causes of autoimmune diseases17,18,19,20.

Antibiotics given to treat infections wipe out the flora in the gastrointestinal tract that help protect the gut from fungal overgrowth and amebic parasites, help the body breakdown complex foods, and synthesize vitamins like B12 and biotin.  With the normal flora wiped out, the gut becomes inflamed, and leaky gut develops.  The end result is often irritable bowel syndrome, which can lead to fungal overgrowth of the gut (candidiasis),chronic fatigue syndrome, autoimmune disease, and even cancer15.

How then to best protect your gastrointestinal tract?  Pharmaceutical drugs havegenerally proven ineffective in treating leaky gut, irritable bowel syndrome, Crohn’s disease and other conditions associated with leaky gut.  But there is a natural remedy that is very effective is healing damaged gut lining and restoring normal permeability. That remedy is colostrum, nature’s first food.  Colostrum has been clinically proven toheal the damage and promote the growth of healthy intestinal flora while cooling the inflammation and supplying needed nutrients to help recover from nutrient deficiencies21.

Colostrum is the first milk produced by the mother, and its principal function is to promote the development of the GI tract in the newborn.  The same factors that fulfillthis function are the same factors that help protect grownups (including children beyondinfancy) against leaky gut, Crohn’s disease, colitis, necrotizing enterocolitis, irritable bowel syndrome and other similar conditions22.  Colostrum contains many growthfactors, such as epithelial growth factor, transforming growth factor beta, which repairdamaged tissue23 and restore normal permeability24 through its anti-inflammatory activity25.  It also has been shown to both prevent and heal the damage caused by NSAIDs by repairing the epithelial lining cells of the GI tract26,27,28.  Colostrum also supports the growth of healthy flora29,30 while killing off harmful bacteria, like Helicobacter pylori31, a major cause of gastric ulcers in humans.

Colostrum is now available in a product designed to provide the best protection for your gastrointestinal tract, called GastroDefenseTM, produced by Sovereign Laboratories.  It contains the highest quality colostrum in the world that is collected year round from cows in the Southwest United States.  It is certified organic and fresh.  It is processed inthe only plant designed from the ground up to process colostrum using state-of-the-artequipment.  The colostrum is then coated with a lipid film that protects it from digestive enzymes during its passage through the stomach so that it can get to the intestines intact. There are no known side effects, and it is safe for children of all ages.

GastroDefenseTM also contains calcium carbonate to help reduce excess stomach acidand peppermint to soothe the stomach. Protect your health by providing your gastrointestinal tract the best protection available.

1. Bjarnason, I, Zanelli, G, Prouse, P, Williams, P, Gumpel, MJ, Levi, AJ.  Effect of non-steroidal anti-inflammatory drugs on the human small intestine. Drugs 32(Suppl 1):35-41 (1986).

2. Fratkin, JP.  Leaky Gut Syndrome: A Modern Epidemic. http://www.hpakids.org/holistic-health/articles/149/1/Leaky-Gut-Syndrome (2004).

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16. Galland, L.  Leaky Gut Syndromes: Breaking the Vicious Cycle. Foundation for Integrative Medicine.  www.mdheal.org/leakygut.htm.

17. Bloembergen, P, Hofhuis, FM, van Dijk, H, Verhagen, C, Rademaker, PM, Willers, JM.  Endotoxin- induced auto-immunity in mice. I. Time and dose dependence of production and serum levels of antibodies against bromelain-treated mouse erythrocytes and circulating immune complexes. International Archives of Allergy and Applied Immunology 84(3):291-297 (1987).

18. Bloembergen, P, van Dijk, H, Hofhuis, FM, van den Heiligenberg, P, Willers, JM.  Endotoxin-induced auto-immunity in mice. II. Reactivity of LPS-hyporesponsive and C5-deficient animals. International Archives of Allergy and Applied Immunology 86(4):370-374 (988).

19. Bloembergen, P, Hofhuis, FM, Hol, C, van Dijk, H.  Endotoxin-induced auto-immunity in mice. III. Comparison of different endotoxin preparations. International Archives of Allergy and Applied Immunology 92(2):124-130 (1990).

20. Rona, ZP.  Altered Immunity and Leaky Gut Syndrome. http://www.mold-survivor.com/leaky_gut_syndrome.html

21. Borody, TJ, Surace, R, Warren, E. Tunnel vision in the bowel. In: Emergent bioactive components and their application in health. Global Active Summit Proceedings, Hamilton, New Zealand, (2001).

22. Carver, JD, Barness, LA. Trophic factors for the gastrointestinal tract. Clinical Perinatology 23(2):265-285 (1996).

23. Gastrointestinal Inflammation and Repair Group, Imperial College, London (2003).  Unpublished research.

24. Prosser, C, et al. Reduction in heat induced gastrointestinal hyperpermeability in rats by bovine colostrum and goat milk powders. Journal of Applied Physiology 96:650-654 (2004).

25. Goldman, AS, et al. Anti-inflammatory properties of human milk. Acta Paediatrica Scandinavica 75(5):689-695 (1986).

26. Playford, RJ, Floyd, DN, MacDonald, CE, Calnan, DP, Adenekan, RO, Johnson, W, Goodlad, RA, Marchbank, T. Bovine colostrum is a health food supplement which prevents NSAID induced gut damage. Gut 44:653-658 (1999).

27. Playford, RJ, MacDonald, CE, Calnan, DP, Floyd, DN, Podas, T, Johnson, W, Wicks, AC, Bashir, O, Marchbank, T. Co-administration of the health food supplement, bovine colostrum, reduces the acute non-steroidal anti-inflammatory drug-induced increase in intestinal permeability. Clinical Science 100:627-633 (2001).

28. Playford, RJ, Ghosh, S.  Cytokines and growth factor modulators in intestinal inflammation and repair. Journal of Pathology 205(4):417-425 (2005).

29. Lonnerdal, B. Nutritional and physiologic significance of human milk proteins. American Journal of Clinical Nutrition 77(6):1537S-1543S (2003).

30. Korhonen, H, Marnila, P, Gill, HS.  Bovine milk antibodies for health. British Journal of Nutrition 84(Suppl 1):S135-S146 (2000).

31. Korhonen, H, Syvaoja, EL, Ahola-Luttila, H, Sivela, S, Kopola, S, Husu, J, Kosunen,TU.  Bactericidal effect of bovine normal and immune serum, colostrum and milk against Helicobacter pylori. Journal of Applied Bacteriology 78:655-662 (1995).

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