What Are Immunoglobulins

What Are Immunoglobulins

What Are Immunoglobulins? 

Immunoglobulins are substances formed from human plasma and contain antibodies that aid immune response. They are essential for the building a healthy immune system of neonatal mammals after birth.

Following mammalian birth, immunoglobulins are transported from the mammary epithelial cells to the mammary gland via colostrum and milk ejection during suckling. Next, immunoglobulins enter the gastrointestinal (GI) tract of the neonate and provide protective benefits.

Immunoglobulins are produced by white blood cells, and there are five classes of immunoglobulins:

  • Immunoglobulin A (IgA)
  • Immunoglobulin G (IgG)
  • Immunoglobulin M (IgM)
  • Immunoglobulin E (IgE)
  • Immunoglobulin D (IgD)

Immunoglobulins bind, recognize, and destroy bacteria, toxins, viruses, and other antigens. The body produces antibodies to fight off antigens. Then, the next time an antigen enters the body, it stimulates the production of identical antibodies.

In most instances, doctors will measure IgA, IgG, and IgM together. This enables doctors to study the immune function relative to infection and autoimmune diseases.

Immunoglobulins and Colostrum

Additionally, the importance of immunoglobulins is key to understanding why bovine colostrum supplementation is critical to human health especially for those who were never breastfed as an infant. Immunoglobulins and other active immune-modulating components in bovine colostrum have been shown to help reduce the risk of autoimmune, infectious, and idiopathic (unknown cause) diseases, including:

  • Chicken pox
  • Hepatitis
  • Measles

Raw, fresh bovine colostrum contains several different types of immunoglobulins:

  • IgA: Is an antibody with potent, broad-based antiviral and antibacterial abilities by which it helps prevent infection.
  • IgG: Used to treat immune system problems and infections. Bovine colostrum contains more IgG than any other immunoglobulin.
  • IgM: Found in the blood and lymph fluid, IgM antibodies are the first type of antibodies to form in response to an infection.
  • IgE: Located in the lungs, skin, and mucous membranes, IgE antibodies are frequently associated with allergic reactions and parasitic infections.
  • IgD: Produced in a secreted form that is found in blood serum, IgD has been studied extensively, and research indicates the immunoglobulin supports vital immunological functions.

Clearly, immunoglobulins have a vital role in mammalian health. These key components must also be present (remain intact) in bovine colostrum supplements if they are to be effective.

It is important to note that not all bovine colostrum products contain the same types of immunoglobulins or immunoglobulins in therapeutic quantities.

When it comes to bovine colostrum supplements, it pays to choose a product that includes a wide range of immunoglobulins.

Key reasons to select a bovine colostrum product that contains many types of immunoglobulins are:

  • Enhanced Immune Function: Bovine colostrum with immunoglobulins can help an individual balance and maintain immune function.
  • Combat Harmful Pathogens: Immunoglobulins in bovine colostrum help lower the risk of harmful pathogens, thereby preventing or minimizing infections.
  • Safeguard the Stomach Lining: Bovine colostrum with immunoglobulins has been shown to help safeguard and heal the GI tract and stomach lining.

Immunoglobulins are powerful bioactive components that may help an individual speed up treatment and recovery from disease. As such, bovine colostrum supplements that contain several different types of immunoglobulins are a superior choice over alternative products containing low levels or fewer immunoglobulins.

Several Studies Highlight the Benefits of Immunoglobulins in Bovine Colostrum 

Over the years, researchers have performed a variety of studies to learn about the impact of immunoglobulins in bovine colostrum, as well as the effects of bovine colostrum supplementation on humans.

In one study, 35 colostrum samples were obtained from healthy dairy cows from four farms in Argentina. Seventy-seven percent of the colostrum samples contained IgG antibodies that could help individuals combat enterohemorrhagic Escherichia coli (EHEC), a primary cause of a condition that affects blood and blood vessels in the kidneys. The study indicated that bovine colostrum contains IgG and other antibodies that recognize proteins that may cause EHEC. Also, the study revealed colostrum retains a high level of hemolysis inhibition in comparison to other substances.

Another study was used to evaluate the impact of oral immunoglobulin intake for medical nutrition from natural sources. In the study, researchers assessed bovine milk immunoglobulin that was purified from hyperimmunized cows against four human rotavirus serotypes. Among infants who received this immunoglobulin over the course of five days, 43% maintained rotavirus-neutralization activity against bovine rotavirus V1005, human rotavirus Wa (serotype 1), and simian rotavirus SA-11 in cell culture. This shows that oral intake of bovine colostrum is a potentially safe, reliable treatment for various gastrointestinal (GI) infections.

Why Is Colostrum-LD® the Right Choice for Bovine Colostrum Supplementation? 

All bovine colostrum supplements are not created equal. Whereas some bovine colostrum products claim to contain high quantities of immunoglobulins and other nutritional components, few can simultaneously help people boost and balance the immune function, combat bacteria and viruses, and support the protection and healing of the stomach lining. If colostrum is pasteurized at high heat for long periods of time, only a percentage of the immunoglobulins remain, and all of the other health-enhancing bioactives are destroyed.

Colostrum-LD® from Sovereign Laboratories contains 25%-30% immunoglobulins, along with other bioactive components that have been shown to support improved immune function and response. Colostrum-LD® is flash pasteurized (for safety) and dried with low heat to maintain the highest quality and bioavailability.

In addition to immunoglobulins, some of the bioactive components in Colostrum-LD® are:

  • Growth Factors: Growth factors help stimulate cellular repair, growth, differentiation, and maturation and regulate many cellular processes within the body.
  • Lactoferrin: As an iron-binding glycoprotein. Lactoferrin is a powerful antimicrobial component that binds metals ions that are necessary for bacterial metabolites, and it helps the body fight off harmful bacteria.
  • Lactalbumin: As a water-soluble protein, lactalbumin contains many essential amino acids that are paramount for the body to grow and develop.
  • Lysozome: Works in conjunction with lactoperoxidase, IgA, and lactoferrin. Lysozome helps assist the immune system by disrupting the cell walls of harmful bacteria.
  • Proline-Rich Polypeptides (PRPs): PRPs help initiate and balance immune responses and boost the thymus gland’s ability to release factors that help regulate immune functions in the body.

Colostrum-LD® also features a unique liposomal delivery (LD) system that ensures maximum effectiveness of the product’s nutritional components. The LD system helps colostrum readily dissolve in liquids, bypass digestion, and circulate throughout the body to reach organs and cells. It even helps make colostrum’s components up to 1,500% more bioavailable than other bovine colostrum products without liposomal delivery.

Lastly, Colostrum-LD® provides essential support to help people overcome the effects of intestinal hyper-permeability, aka a leaky gut, which is believed to be responsible for virtually all types of automimmune conditions, allergies, and chronic diseases. Colostrum-LD® has been shown to prevent an increase in GI permeability due to nonsteroidal anti-inflammatory drugs (NSAIDs), modulate tight junction permeability, and much more.

Colostrum-LD® is a bovine colostrum product that helps support the health and well-being of all individuals. To learn more about Colostrum-LD®, please check out our website.