The growing problem of leaky gut syndrome, or intestinal permeability, has triggered a health crisis in Western civilizations, the likes of which we may be wholly unprepared to deal with. The chronic and systemic inflammation resulting from a leaky gut is believed to be responsible for nearly every type of allergy, autoimmune condition, and chronic disease. Many physicians now agree that nearly everyone will die of an autoimmune condition; premature death will be preceded by physical and mental pain, disability, and suffering. A shortened lifespan and unfulfilled potential need not be our fate, but we need to take action early and consistently to heal the gut.
Although some healthcare providers espouse leaky gut supplements such as probiotics, L-glutamine, or glutathione, these only provide some symptom relief but not true healing. Only the growth factors in colostrum can repair the tissue that lines the G.I. tract, and Colostrum-LD® is the only clinically proven supplement for leaky gut. Colostrum-LD® contains verified quantities of the growth factors necessary to heal leaky gut, making it the ideal supplement for leaky gut as well as immune health.
Much of the early leaky gut research dating back to the early 2000's was done with powdered colostrum provided by Sovereign Laboratories. Some of the most promising leaky gut research includes:
Davison G, Marchbank T, March DS, Thatcher R, Playford RJ. Zinc carnosine works with bovine colostrum in truncating heavy exercise-induced increase in gut permeability in healthy volunteers. American Journal of Clinical Nutrition. 2016 Aug;104(2):526-36. A combination of zinc carnosine and colostrum increased epithelial resistance and the tight junction structure, which may have value for athletes susceptible to leaky gut syndrome and in the prevention of heat stroke in military personnel.
Blais M, et al. A gene expression programme induced by bovine colostrum whey promotes growth and wound-healing processes in intestinal epithelial cells. Journal of Nutritional Science. 2014 Nov 13;3:e57. Colostrum specific bioactive content could be beneficial for intestinal epithelial cell homoeostasis by controlling biological processes implicated in wound healing through a precise gene expression programme.
Marchbank T, et al. The nutriceutical bovine colostrum truncates the increase in gut permeability caused by heavy exercise in athletes. American Journal of Physiology. Gastrointestinal and Liver Physiology 2011;300(3):G477-84. Colostrum may have value in enhancing athletic performance and preventing heat stroke.
Mir R, Singh N, Vikram G, Kumar RP, Sinha M, Bhushan A, Kaur P, Srinivasan A, Sharma S, Singh TP. The structural basis for the prevention of nonsteroidal anti-inflammatory drug-induced gastrointestinal tract damage by the C-lobe of bovine colostrum lactoferrin. Biophysical Journal. 2009 Dec 16;97(12):3178-86. The C-lobe of lactoferrin, a component of bovine colostrum, can be exploited for the prevention of NSAID-induced gastropathy.
Kim JW, et al. Protective effects of bovine colostrum on non-steroidal anti-inflammatory drug induced intestinal damage in rats. Asia Pacific Journal of Clinical Nutrition 2005;14(1):103-7. Administration of bovine colostrum reduced the increase in intestinal permeability, enteric bacterial overgrowth, protein losing enteropathy and mucosal villous damage of the small intestine induced by diclofenac. Bovine colostrum may have a beneficial effect in prevention of NSAID induced small intestinal injuries.
Prosser C, et al. Reduction in heat-induced gastrointestinal hyperpermeability in rats by bovine colostrum and goat milk powders. Journal of Applied Physiology 2004;96(2):650-4. Bovine colostrum powder can partially alleviate the effects of hyperthermia on gastrointestinal permeability in the intact animal. The protective effect may involve modulation of tight junction permeability.
Playford RJ, et al. Co-administration of the health food supplement, bovine colostrum, reduces the acute non-steroidal anti-inflammatory drug-induced increase in intestinal permeability. Clinical Science 2001;100:627-633. This study showed that colostrum also prevents an increase in gastrointestinal permeability due to NSAID use, whereas NSAID use alone without colostrum causes an increase in permeability.
Playford RJ, et al. Colostrum and milk-derived peptide growth factors for the treatment of gastrointestinal disorders. Am J Clin Nutr. 2000;72(1):5-14. A review article of the research examining the potential benefits of using recombinant peptides or colostral-derived preparations for a wide range of gastroenterologic conditions. Early results are encouraging and authors envisage the standard use of these products in the clinical management of gastrointestinal diseases within the next decade.
Playford RJ, et al. Bovine colostrum is a health food supplement which prevents NSAID induced gut damage. Gut 1999;44:653-658. Although non-steroidal anti-inflammatory drugs (NSAIDs) are very effective in controlling joint pain in arthritis, their use also causes significant, and sometimes fatal, gastrointestinal damage. Supplementation with colostrum, however, significantly reduced and healed injury caused by NSAIDs. TGF stimulates new cell growth and a 20% increase in intestinal villi height. By repairing the intestinal mucosal barrier and increasing the surface area in the gut, more nutrients may be absorbed into the bloodstream.