Liposomal Delivery

Many bovine colostrum supplements are available, but only Colostrum-LD® from Sovereign Laboratories has a proprietary liposomal delivery (LD) system to help increase colostrum's bioavailability. To understand the impact of this delivery system, let's examine LD and Colostrum-LD®.

What Is a Liposome?

As a nutrient and drug delivery system, a liposome consists of a spherical-shaped vesicle. It is composed of one or more phospholipid bilayers that replicate the structure of cell membranes.

Liposomes can be used to encapsulate a nutrient's components. They may range in size from 0.025 micrometers (µm) up to 2.5 µm vesicles, and their half-life varies based on the size and number of bilayers present.

A liposome is generally classified based on unilamellar and multilamellar vesicles. Whereas a unilamellar liposome has a single phospholipid bilayer, a multilamellar liposome has two or more phospholipid bilayers.

Liposomal Definition

Liposomal refers to a form of preparation in which a nutrient's components are delivered via liposomes. With LD, a nutrient is protected as it travels through the gastrointestinal tract to where it may be absorbed most effectively in the body. LD may also help a nutrient's components reach target areas in the body faster and more effectively than non-LD versions. Some research suggests that LD encapsulation results in better performance when compared  to non-LD counterparts.

What Does Liposomal Mean?

Some studies indicate liposomal supplements offer many advantages over traditional oral supplements, such as:

1. Bioavailability

A supplement that offers high bioavailability helps ensure that nutrients reach the bloodstream quickly for fast absorption in body tissues. Bioavailability often varies based on a person's age, health, use of medications, and other factors. Yet, by choosing a supplement that uses LD, an individual can benefit from superior bioavailability.

With an oral supplement, its components may break down during the digestive process. As the body digests the supplement, the product's nutritional components “decompose.” The result: only a small portion of the nutrients reach the bloodstream and are available for use within the body.

Comparatively, LD supplements use liposomes for nutrient delivery — in the case of Colostrum-LD®, liposomes help boost bovine colostrum's bioavailability by up to 1,500%. Colostrum’s natural bioactives are protected against digestive enzymes and intestinal microbes, along with free radicals, i.e. unstable atoms that damage cells. Thanks to liposomes, LD supplements can keep their components intact until they reach the cells, thereby ensuring optimal bioavailability and effectiveness.

2. Side Effects

Some supplements cause diarrhea, bloating, constipation, and other forms of GI distress. Side effects vary based on the supplement's quality, its components (ingredients), and other factors. They may also differ based on the user's age, health, and nutrition.

For supplements that use LD, the side effects may be minimal in comparison to those of non-LD supplements. To date, studies have shown that supplements with LD can be used to help safely deliver anti-fungal medicines, anesthetics, and other drugs to cells throughout the body. Studies also suggest that some LD supplements bypass “digestion” in the GI tract, which helps lower the risk of side effects.

3. Consumption

Liposomal supplements may come in capsules or as a powder that makes them easy to consume. A liposomal supplement capsule can be swallowed on its own or broken apart and consumed as a powder with a glass of water. A liposomal supplement may be sold as a powder, too. Once the supplement is consumed, the LD system helps ensure that its components reach the cells quickly.

What Is a Liposomal Delivery System for Drugs?

An LD system has been studied extensively to aid in drug delivery. Research suggests that liposomes have already had far-flung effects on drug delivery in several biomedical areas. However, many LD challenges persist.

Using a quality drug manufacturing process that ensures the stability of a drug formulation — without impacting the LD system — is sometimes difficult. Also, scaling this process to mass-produce large quantities of LD supplements can be costly and time-intensive, which has prevented some pharmaceutical manufacturers from considering LD.

Along with drug manufacturing challenges, government regulations sometimes make it tough for pharmaceutical companies to integrate an LD system into their supplement manufacturing. Clinical trials of supplements with LD formulations can be complex, due in part to the need for various control groups to analyze the drug delivery system. Thus, a pharmaceutical company may require a significant cost and time investment to develop a safe, effective supplement that receives both government and industry approval.

Liposomal Delivery Benefits

LD helps ensure that pure substances included in a supplement reach the right body tissue and organs, at the right time, every time. The use of LD may help boost a supplement's efficiency; some research suggests that LD supplement dose levels are 10 to 15 times lower than those associated with non-LD supplements. An LD supplement also has essential phospholipids that may deliver health benefits, in addition to the supplement components that they encapsulate.

Furthermore, LD helps protect against the degrading and inhibitory factors that otherwise hamper a supplement's effectiveness when it reaches the GI tract. Since an LD supplement's components feature a protective barrier, these components are guarded against digestive juices, salts, and alkaline solutions found in the body. An LD supplement also has a protective barrier in place that helps guard against oxidation and degradation that can occur due to external substances.

A Closer Look at the Phospholipids Behind LD

A Closer Look at the Phospholipids

Phospholipids are cell membrane building blocks, and each phospholipid contains the following parts:

1. Choline

Choline is a nutrient found in foods and sometimes sold on its own as a dietary supplement. Some studies indicate choline helps support the structural integrity of cells. Choline may also be used to help produce acetylcholine, a neurotransmitter that supports memory, muscle control, and other brain and nervous system functioning.

2. Phosphate

Phosphate is a form of phosphoric acid; phosphoric acid consists of phosphorus naturally found in the body and may help strengthen the bones and teeth. Phosphates are sometimes used to treat an elevated calcium level in the blood. The addition or removal of phosphate may impact how certain proteins respond in the body. 

3. Glycerol

Glycerol helps form the backbone of fatty acids in fats. It may be converted into glucose in the liver, which then provides energy to support cellular metabolism.

Along with the aforementioned components, each phospholipid has a head and two tails. The head consists of choline, phosphate, and glycerol, and it is hydrophilic (attracted to water). Each tail consists of a long fatty acid chain, and it is hydrophobic (repelled by water).

When placed into a water-based solution, a phospholipid bilayer forms, and this bilayer consists of two rows of phospholipid molecules. In the human body, the phospholipid bilayer serves as an outer cell membrane, and it protects a cell's contents from harmful substances. Proteins interspersed within a cell's phospholipid bilayers allow nutrients to enter and cellular waste products to exit, as well as support intercellular communication.

Phosphatidylcholines (PCs) are among the most powerful phospholipids. They are essential for life and health — despite the fact that they cannot be produced by the human body.

PCs consist of polyunsaturated fatty acids, which include carbon and hydrogen atoms and support cell membrane synthesis and the fat metabolism. Various studies suggest radioactively tagged fatty acids in PCs quickly replace saturated and/or damaged phospholipids in plasma membranes. In doing so, PCs' polyunsaturated fatty acids help facilitate the metabolism of low-density lipids and cholesterol. This helps ensure that blood can quickly and easily move through the circulatory system. It also helps improve the efficiency of plasma membranes, remove and metabolize saturated fats and cholesterol, reduce the body's risk of attack by free radicals, and support the heart, pancreas, and liver function.

How Have PCs Been Used in LD?

PCs have been used in a variety of LD systems to help:

  1. Boost drug solubility
  2. Promote sustained drug release
  3. Ensure the safety of a drug's components
  4. Improve drug penetration

Research into the use of PCs in LD is ongoing, and LD enhancements are likely to continue in the years to come. Today, with Colostrum-LD®, people can enjoy the benefits of a bovine colostrum supplement that uses LD for maximum efficacy.

What Is Colostrum-LD®?

To understand Colostrum-LD®, it is first important to understand bovine colostrum and its impact on human beings.

Colostrum is commonly referred to as "life's first food," and it is produced by mammalian mothers shortly after childbirth. Mammalian mothers can give colostrum to their newborns, and colostrum helps support newborn growth and development.

Colostrum contains carbohydrates, fats, proteins, vitamins, and minerals that may help support immune response and stimulate growth. It also contains immunoglobulins that may aid in the intestinal growth and development of newborns. In one study, researchers found infants who received colostrum experienced higher levels of immunoglobulin G (IgG), an antibody found in blood circulation, five days after birth in comparison to infants who did not receive colostrum. Researchers also noted that colostrum-fed infants had a higher concentration of IgG in contrast to infants who were not given colostrum.

Some studies suggest colostrum may help increase the length, width, and crypt depth of villi, thread-like projections that help fluid or nutrients move into the small intestine. In one study, researchers found that calves given colostrum had a greater villi length, width, and crypt depth than other calves that did not receive colostrum.

Bovine colostrum supplements are readily available online or at health food stores, and they are often intended for use by men, women, children, and even pets. The supplements are typically sold in capsule or powder forms, but only one such supplement has a proprietary LD system — Colostrum-LD®.

Sovereign Laboratories developed its colostrum supplement's LD system over two decades and continues to explore ways to enhance it. The LD system protects the components of Colostrum-LD® against damage as they travel through the stomach and into the small intestine.

Some studies indicate colostrum that lacks LD may clump together in the GI tract. Alternatively, Colostrum-LD® uses an LD system that ensures colostrum's components are dispersed throughout the body for enhanced absorption and effectiveness in comparison to other bovine colostrum supplements.

Colostrum that uses an LD system also helps stop IgG from breaking down in the digestive tract. Research also shows that colostrum with LD does a better job of protecting IgG than colostrum without LD.

What Are the Benefits of Colostrum with LD?

The health benefits of bovine colostrum have been evaluated over the years. With LD, people are more likely to realize the full benefits of colostrum faster than they would if they use colostrum that lacks an LD system.

In areview of 51 clinical studies across 49 publications, researchers found that bovine colostrum may support immune system modulation. Sometimes, the immune system becomes overactive or underactive; this may occur due toleaky gut, a condition that has been frequently associated with autoimmune diseases.

When leaky gut occurs, bacteria, viruses, and other infectious agents penetrate the GI tract and enter the bloodstream. This happens when the barrier between the GI tract and bloodstream is porous due to the use of non-steroidal anti-inflammatory drugs (NSAIDs), excessive consumption of alcohol, nutritional deficiencies, or other issues that affect gut health, including common gut-irritating medications (antibiotics, pain medications, steroids).

Leaky gut disrupts immune response, and it may cause the immune system to become overactive in a detrimental way. When the immune system is unbalanced over a long period of time, help is required to restore the immune system to a state of balance (homeostasis).

Colostrum-LD® is clinically proven to help manage leaky gut and promotes a healthy G.I. tract. The immune  components in Colostrum-LD® may help stimulate an underactive immune system or tone down an overactive one. In that regard , Colostrum-LD® may help restore an underactive or overactive immune system to homeostasis.

Does It Make a Difference If Colostrum-LD® Is Taken as a Capsule or as a Powder?

The LD system of Colostrum-LD® works the same way if the bovine colostrum supplement is consumed as a capsule or powder. However, there are notable differences between Colostrum-LD® capsules and powder that people should consider before they begin using either form of the bovine colostrum supplement.

Colostrum-LD® as a powder starts to work the moment it enters the mouth. It comes in plain and vanilla flavors and can be mixed into room temperature or lukewarm water. Colostrum-LD® powder also tends to be more economical relative to Colostrum-LD® in capsule form.

As a capsule, Colostrum-LD® begins working once it reaches the gut (after the capsule dissolves). Colostrum-LD® capsules are easy to carry on the go and can be taken at the same time as other daily supplements. Plus, Colostrum-LD® capsules can be broken apart and mixed into room temperature or lukewarm water if desired.

Colostrum-LD® powder and capsules include all-natural ingredients and can be consumed daily. Regardless of whether Colostrum-LD® is used as a powder or capsule, the supplement should be taken on an empty stomach approximately 20 minutes before eating for maximum results.

Does Colostrum-LD® Work Faster Than Other Bovine Colostrum Supplements?

The time it takes for the results of a bovine colostrum supplement to become noticeable varies from person to person. Since Colostrum-LD® has an LD system, the supplement may help maximize the benefits of colostrum.

In some instances, people start to experience the results of Colostrum-LD® within a few days of first use, with full results becoming transparent up to six weeks after initial use. People who take Colostrum-LD® daily, follow the supplement's instructions, and maintain a healthy lifestyle may enjoy the full results of colostrum in time.

What Makes Colostrum-LD® Unique?

Along with the LD system, Colostrum-LD® is unique in that it is produced by Sovereign Laboratories and its founder Douglas Wyatt. Colostrum-LD® is the leading colostrum supplements benefiting from their 25 years of research and development.

Sovereign Laboratories develops natural products designed to promote optimal health, vitality, aesthetics, and healthy aging. It provides Colostrum-LD®, the top-selling brand of bovine colostrum in the United States, as well as other nutritional supplements backed by comprehensive research.

Douglas Wyatt, the founder of Sovereign Laboratories, is a leading authority on bovine colostrum and established the gold standard for processing raw bovine colostrum into supplements. He also developed an LD system to enhance the bioavailability of colostrum and other nutritional supplements.

Sovereign Laboratories is proud to provide Colostrum-LD®, the only U.S. colostrum certified OU-D Kosher and Halal and processed in FDA- and USDA-certified facilities. Clinical studies have shown Sovereign Laboratories' colostrum contains higher levels of key components in comparison to other U.S and New Zealand colostrum supplements. Moreover, Colostrum-LD® is suitable for lactose-free diets and has been independently tested and carries Swiss Food Safety (SGS) certification.

Is Colostrum-LD® Right for You?

For those who are considering Colostrum-LD® and may have questions, it is important to consult with a doctor. You can also do research online via PubMed to review the scientific literature on the benefits of colostrum supplementation and the individual components that comprise colostrum.

If a person decides to use bovine colostrum, Colostrum-LD® is a great option. The LD system utilized in Colostrum-LD® helps preserve the integrity of colostrum's components. Colostrum-LD® contains maximum quantities of immunoglobulins, growth factors, lactoferrin,colostrum polypeptides, and other nutritious components that may help support a healthy gut and other body systems. As such, Colostrum-LD® provides a bovine colostrum supplement that may be beneficial for people to integrate into their everyday diet.

Learn More About Colostrum-LD®

Sovereign Laboratories is happy to teach people about our LD system, as well as our bovine colostrum and its benefits. To learn more,please read our blog or contact us today.